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J Korean Soc Emerg Med > Volume 10(2); 1999 > Article
Journal of The Korean Society of Emergency Medicine 1999;10(2): 165-174.
Effect of Pentoxifylline on Ischemia-Reperfusion Injury of Brain Following Cardiac Arrest in Rats
Si Kyoung Jeong, Kyu Nam Park, Seung Hyun Park, Dong Rul Oh, Won Jae Lee, Eun Young Rue, Kyoung Ho Choi, Young Min Kim, Woon Jeung Lee, Se Kyung Kim
BACKGROUND: Two major events occurring in the cerebral hemodynamics after successful resuscitation from cardiac arrest are reactive hyperemia and postischemic hypoperfusion. In this study, we examined the effect of Pentoxifylline(PTX) on the rat brain following cardiac arrest.
Fourteen rats were anesthetized and artificially ventilated. Cardiac angst was produced by chest compression and clamping of tracheal tube far 3 minutes in ketamine anesthetized rats. Circulation was restored by standard cardiopulmonary resuscitation methods. In 7 rats, PTX 10mg/kg was infused at 10min after cardiac angst(PTX group). In the other 7 rats, same amount of normal saline was infused(control group).
In both groups, hemodynamic variables, neurologic deficit(ND) score and histopathologic findings of hippocampal CA1 neurons were observed. Hemodynamic variables and ND score were not significandy different between two groups. Delayed ischemic neurons of hippocampal CA1 were decreased in PTX group(2.2+/-2.4%) compared with control group(9.1+/-1.2%). CONCLUSIONS : We conclude that PTX prevented development of delayed ischemic neurons in hippocampal CA1 after cardiac arrest. PTX may be useful in emergency situations following cardiac arrest.
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