|
|
Journal of The Korean Society of Emergency Medicine 1998;9(4): 614-621. |
| Developing of Systemic Inflammatory Response Syndrome and Serum TNF-alpha Level in Multiple Trauma Patients |
| Hyun Kim, Kang Hyun Lee, Jong Cheon Lim, Jun Hwi Cho, Bum Jin Oh, Sung Oh Hwang |
|
|
|
|
|
|
| ABSTRACT |
BACKGROUND AND PURPOSE:
The systemic inflammatory response syndrome(SIRS), as defied recently by critical-care specialists, may result from various etiologies including infection, bum, or trauma. The purpose of this study was to determine whether TNF- alpha is associated with the development of systemic inflammatory response syndrome caused by multiple trauma.
METHODS:
The study population consisted of 21 patients with multiple trauma presented emergency department within 2 hours after insult were enrolled in this study Multiple blood samples were serially drawn to measure seam TNF-alpha level on admission, 12 hours, 24 hours, and every day until 5 days after injury. Serum TNF-alpha was measured by ELISA ("Sandwich type"). Blood samples of fifteen volunteers were used as a reference value far serum TNF-alpha.
RESULTS:
Serum TNF-alpha. levels of SIRS group were persistency elevated above reference value until 3 days after on admission. Peak seam TNF-alpha level at 12 hours after admission was higher in SIRS group than non-SIRS group(p< 0.05). There was no significant correlation between injury severity score and TNF-alpha levels on regression analysis, all patients with ISS higher than 16 had SIRS. No one had SIRS among patients with ISS less than 16.
CONCLUSION:
the result of this study suggests that persistent elevation of TNF-alpha and degree of injury severity are associated with the development of systemic inflammatory response syndrome in multiple trauma. |
|
|
|
PDF Links
Full text via DOI 
Download Citation 
