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Journal of The Korean Society of Emergency Medicine 1994;5(1): 26-33. |
| COMPARISON OF HEMODYNAMIC EFFECTS OF INTRAOSSEOUS AND CENTRAL VENOUS ROUTES OF PENTASPAN(10% PENTASTARCH) FOR RESUSCITATION OF HEMORRHAGIC SHOCK IN A SWINE MODEL |
| Won Jae Lee, Kyu Nam Pak, Ju Il Hwang, Keun Woo Rhim, Se Kyung Kim |
| Department of Emergency Medicine, Catholic University Medical College |
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Published online: July 31, 1994. |
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| ABSTRACT |
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Venous access remains often as a clinical problem for pediatric patients in hemorrhagic shock state. This study compares resuscitation with PENTASPAN(10% pentastarch) by central venous and intraosseous route in a hemorrhagic shock model. The swines were bled to a mean arterial pressure of 30 mmHg. This state of shock was sustained for 30 minutes. Resuscitation was performed with Pentaspan infused at 50 mL/min by a manual pressure. The hemodynamic response to Pentaspan resuscitation was comparable in both group. There was no significant difference in mean arterial pressure, heart rate, cardiac output, pulmonary capillary wedge pressure, pulmonary artery pressure, arterial oxygen saturation, and mixed venous oxygen saturation.
For fixed rate infusion, intraosseous resuscitation with Pentaspan is as effective as that infused by central venous route in improving hemorrhagic shock state.
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| Key words:
Intraosseous infusion, hemorrhagic shock |
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