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Journal of The Korean Society of Emergency Medicine 1995;6(1): 184-191. |
| THE ANALYSIS OF CHARACTERISTICS AND PROGNOSIS OF DAPSONE INTOXICATION PATIENTS |
| Seung Whan Kim, Hong Du Goo, Sung Pil Chung, Seok Joon Jang, Ho Sik Shim |
| Department of Emergency Medicine, Severance Hospital, Yonsei University College of Medicine |
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Published online: June 30, 1995. |
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| ABSTRACT |
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We reviewed 26 dapsone intoxication patients who had visited Severance Hospital Emergency Care Center from January 1991 to January 1995 : 13 of them ingested intentionally, but the other ingested accidentally. Among the admitted patients the highest and lowtheest initial value of methemoglobin level is 59.6% & 10.1%. The frequency of symptoms at presentaion was following 16 patients complained cyanosis of lip area, 10 patients complained dyspnea, 4 patients complained mental change, 4 patients complained vomiting, 2 patients complained nausea. The initial level of methemoglobin was less than 50% except in one patient. In the view points of total doses of methylene blue used, less than 100mg was used in 9 patients(34.6%) but in one case, amount of 6400mg was loaded. There were 5 patients(19.2 %) in September & 4 patients (15.4%) in January. In respect of result, there were 13 discharged cases (50% ) for symptom improvement, and 5 mortality cases(19.2%). The transferred cases from Gangwon-do account 19 patients(73.1 %). All of them is not directly emergency care center visiting patients but transferred patients from remotely located hospitals. Dapsone intoxication results in severe tissue hypoxic symptoms from malfunction of normal hemoglobin thus only with appropriate available doses of methylene blue & activated charcoal, good outcomes will be expected. If aggressive therapy such as hemodialysis is introduced in treatment of severe dapsone intoxication, the outcomes may be slightly improved better than in other supportive care cases. |
| Key words:
Dapsone, Methylene blue |
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