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Journal of The Korean Society of Emergency Medicine 1996;7(3): 415-419. |
| A CASE OF DYSTONIA INDUCED BY ZIPEPROL DIHYDROCHLORIDE |
| Sung Woo Lee, Chung Min Chun, Yun Sik Hong |
| Department of Emergency Medicine, Korea University College of Medicine |
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Published online: September 30, 1996. |
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| ABSTRACT |
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Zipeprol dihydrochloride is a non-essential but widely used antitussive, which is not considered as being capable of creating dependence or abuse liability. But some experimental study (Morreti-V, 1989) resulted indicate zipeprol as moderate opioid agonist. And zipeprol abuse and it's side-effect have been rarely reported. It included seizure, cerebral edema, abnormalities of posture and gait
We have experienced a case of parkinsonic dystonic movement disorder induced by zipeprol abuse. A 21-year-old male was admitted in August, 1995, with a symptom of abnomalities of posture and gait. He had ingested 3000mg zipeprol per day for 3 years. He recovered after anticholinergics therapy. His Brain MRI, EEG showed no abnomality.
High doses of zipeprol, therefore, exert a generalized irritating cortical effect together with a localized, neurotoxic effect which proved to be transient Zipeprol should be much more strictly controlled and more through follow-up in respect of side-effects of therapeutic use and abuse are recommended.
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| Key words:
Zipeprol, Dystonia |
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