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Journal of The Korean Society of Emergency Medicine 2025;36(4): 163-166. |
| Acute tubulointerstitial nephritis induced by glyphosate ammonium herbicide intoxication: a case report |
Dayeong Kang1
, Kyung Hoon Sun2
, Youngmin Yoon3
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1Hanmaum Internal Medicine Clinic, Gwangju, Korea
2Department of Emergency Medicine, Chosun University Hospital, Chosun University School of Medicine, Gwangju, Korea
3Division of Nephrology, Department of Medicine, Chosun University Hospital, Chosun University School of Medicine, Gwangju, Korea |
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Received: January 15, 2024; Revised: October 11, 2024 Accepted: November 7, 2024. Published online: August 28, 2025. |
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| ABSTRACT |
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Glyphosate, the most widely used broad-spectrum, nonselective herbicide, finds applications across various domains. Acute tubulointerstitial nephritis (ATIN) represents a common cause of acute kidney injury (AKI). In this report, we present a case of ATIN following glyphosate ingestion. A 76-year-old male was admitted to the emergency department after a suicide attempt involving glyphosate ingestion. The patient developed respiratory distress and oliguric AKI. We administered ventilator support and continuous renal replacement therapy. Although respiratory distress improved with conservative treatment, renal function remained severely impaired. Renal biopsy confirmed ATIN with characteristic tubular injuries and inflammatory cell infiltration. Treatment with prednisolone successfully restored renal function without requiring hemodialysis. This case highlights the potential association between glyphosate exposure and ATIN, suggesting the need for further investigation into its nephrotoxic potential. |
| Key words:
Glyphosate poisoning; Acute tubulointerstitial nephritis; Prednisolone; Renal biopsy |
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