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J Korean Soc Emerg Med > Volume 22(3); 2011 > Article
Journal of The Korean Society of Emergency Medicine 2011;22(3): 248-252.
Prophylactic Antiemetic Effect of Metoclopramide Against Intravenous Contrast Media-Induced Nausea in the Emergency Department
Hyun Soo Park, Gil Joon Suh
1Department of Emergency Medicine, Dankook University Hospital, Cheonan, Korea.
2Department of Emergency Medicine, Seoul National University College of Medicine, Seoul, Korea. suhgil@snu.ac.kr
Iodine contrast media used in computed tomography (CT) often induces nausea in patients. This study evaluated the prophylactic effect of metoclopramide against nausea induced by intravenous contrast media.
A prospective, double-blinded, randomized controlled trial was performed in the emergency department of an urban teaching hospital. Adult patients(>15 years old), who required enhanced CT scans, were infused with 52 ml normal saline solution mixed with either 10 mg/2 ml metoclopramide or 2 ml normal saline over 10 minutes prior to the CT scan. After the scan, the patients were asked about nausea. Patients who had any other cause for their nausea or had received metoclopramide prior to the study were excluded.
In total, 69 patients were analyzed. The metoclopramide group contained 37 patients, and the placebo group contained 32 patients. Five patients in the placebo group complained of nausea(15.6%), whereas none of the patients in the metoclopramide group experienced nausea (Fisher's exact test, p=0.018).
Metoclopramide can prevent nausea induced by intravenous iodine contrast media.
Key words: Computed tomography, Contrast media, Metoclopramide
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