Correlation between the size of the ureter stone and the neutrophil-lymphocyte ratio, platelet lymphocyte ratio, and C-reactive protein in patients with ureter stone visiting the emergency department

Jeong, Won Dong; Choi, Woo-Ik; Jung, Wonho; Park, Dong Jin; Seo, Young Jin; Lee, Kyung Seop; Jeon, Jae Cheon

J Korean Soc Emerg Med > Volume 32(5); 2021 > Article

Original Article

Journal of The Korean Society of Emergency Medicine 2021;32(5): 394-399.

응급실을 내원한 요관결석 환자에서 크기가 5 mm 이상인 집단과 5 mm 미만인 집단 간의 임상적 특성과 neutrophil-lymphocyte ratio, platelet lymphocyte ratio, C-reactive protein의 비교

정원동¹

¹계명대학교 의과대학 응급의학교실
²계명대학교 의과대학 비뇨의학교실
³동국대학교 의과대학 비뇨의학교실

Correlation between the size of the ureter stone and the neutrophil-lymphocyte ratio, platelet lymphocyte ratio, and C-reactive protein in patients with ureter stone visiting the emergency department

¹Department of Emergency Medicine, University of Keimyung College of Medicine, Daegu, Korea
²Department of Urology, University of Keimyung College of Medicine, Daegu, Korea
³Department of Urology, Dongguk University College of Medicine, Gyeongju, Korea

Correspondence

Jae Cheon Jeon ,Tel: 053-258-7896, Fax: 053-258-6305, Email: cheon9803@naver.com,

Received: July 9, 2020; Revised: August 26, 2020 Accepted: September 25, 2020. Published online: October 31, 2021.

ABSTRACT

Objective:
The size and location of ureter stones are important factors in their spontaneous passage. We compared the clinical characteristics and neutrophil-lymphocyte ratio (NLR), platelet lymphocyte ratio (PLR), and C-reactive protein (CRP) of patients who visited the emergency department with ureter stones of ≥5 mm and <5 mm in size.
Method:
We retrospectively reviewed 699 patients who visited the emergency department of two medical centers from January 2017 to December 2019. We compared microscopic hematuria, pyuria, NLR, PLR, CRP, the grade of hydronephrosis, and the location of ureteral calculi between the two groups.
Results:
There were 419 patients with ureter stones less than 5 mm and 280 patients with stones more than 5 mm in size. NLR was 2.82 (1.44-4.73) and 3.12 (1.94-5.75) in patients with stones <5 mm and ≥5 mm, respectively (P=0.001). PLR was 117.2 (88.2-164.9) and 136.0 (98.9-199.7) in patients with stones <5 mm and ≥5 mm, respectively (P=0.001). CRP was 0.29 (0.29-0.29) and 0.29 (0.29-1.04) in patients with stones <5 mm and ≥5 mm, respectively (P<0.001). The proportion of microscopic hematuria was 84.7% and 76.4% in patients with stones <5 mm and ≥5 mm, respectively (P=0.006). The proportion of pyuria was 20.5% and 41.8% in patients with stones <5 mm and ≥5 mm, respectively (P=0.01).
Conclusion:
In patients with ureter stones ≥5 mm, CRP, NLR, and PLR were significantly higher than patients with ureter stones <5 mm. However, further studies are needed before using these indicators to make clinical decisions regarding ureteral stone management.

Key words: Ureteral calculi; Neutrophil-to-lymphocyte ratio; Platelet-to-lymphocyte ratio; C-reactive protein