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J Korean Soc Emerg Med > Volume 34(2); 2023 > Article
Journal of The Korean Society of Emergency Medicine 2023;34(2): 177-183.
Is increased Mean platelet volume associated with neurologic outcome after non-traumatic subarachnoid hemorrhage?
Cheong Hun Seo1 , Young Shin Cho1 , Young Ju Lee1 , Hye Young Jang1 , Joon Bum Park1 , Hye Jin Chung1 , Sang Il Kim1 , Beom Sok Seo1 , Young Wha Sohn1 , Su Yeon Park2,3
1Department of Emergency Medicine, Soonchunhyang University College of Medicine, Seoul, Korea
2Department of Biostatistics, Soonchunhyang University Seoul Hospital, Seoul, Korea
3Department of Applied Statistics, Chung-Ang University, Seoul, Korea
Correspondence  Young Shin Cho ,Tel: 02-710-3117, Fax: 02-709-9083, Email: emcys0819@gmail.com,
Received: August 21, 2022; Revised: October 25, 2022   Accepted: November 8, 2022.  Published online: April 30, 2023.
ABSTRACT
Objective:
This study evaluated the clinical usefulness of mean platelet volume (MPV) for predicting functional outcomes in subarachnoid hemorrhage (SAH) patients.
Method:
This is a retrospective analysis of patients who were diagnosed with SAH in the emergency room. Based on their modified Rankin Scale (mRS) score, patients were divided into two groups: 0-2 (good outcome) and 3-6 (poor outcome). Univariable and multivariable analyses were performed to investigate whether MPV, along with other multiple factors, was associated with poor prognosis. Receiver operating characteristic (ROC) curve analysis was performed to determine the value of MPV as a predicting factor of neurological prognosis. Compared to other factors, Hunt Hess grade (HHG) and modified Fisher grade (mFG) considerably influenced the outcomes in both groups (Model 1; model including all factors). Hence, a new model (Model 2) was constructed, comprising multiple factors excluding these two factors.
Results:
A total of 143 patients were included in this study. Although MPV was different between the two groups, it was not a significant factor in Model 1 in the multivariable analysis. In Model 2, MPV (odds ration [OR], 1.71; 95% confidence interval [CI], 1.05-2.8), age (OR, 1.06; 95% CI, 1.03-1.1), and surgical treatment (OR, 0.37; 95% CI, 0.15-0.87) were significant factors related to poor outcomes. Area under the curve (AUC) of Model 1 was 0.93, 0.85 in HHG; 0.78 in Model 2, 0.65 in mFG, and 0.62 in MPV.
Conclusion:
Although MPV differed significantly between the good and poor outcome groups, it is insufficient to predict poor outcomes in SAH patients as an independent biomarker.
Key words: Subarachnoid hemorrhage; Mean platelet volume
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