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Journal of The Korean Society of Emergency Medicine 1995;6(1): 99-106. |
| "TORSADES DE POINTES" VENTRICULAR TACHYCARDIA ASSOCIATED WITH TERFENADINE AND KETOCONAZOLE |
| Seung Hyun Park, Ki Jung Lee, Won Jae Lee, Keun Woo Lim, Seung Jin Yu, Il Young Park, Se Kyung Kim, Dong Hun Kang |
| Department of Emergency Medicine, Kangnam St' Mary Hospital, Catholic University Medical College |
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Published online: June 30, 1995. |
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| ABSTRACT |
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Torsades de pointes is a form of polymorphic ventricular tachycardia that is associated with prolongation of the QT interval, characterized by QRS complexes of progressively changing amplitude and contour that seem to revolve around the isoelectric line. The most common cause of Torsades de pointes induced by antiarrhythmic agents, occupying in certain drugs or toxin, electrolyte disturbance, congenital QT prolongation syndrome.
Cardiotoxicity terfenadine, in overdose a widely used, nonsedating antihistamine, has been reported.
Case after administration of terfenadine and ketoconazole causing syncope and torsades de pointes have been reported in recommended dose.
We report a case of QT prolongation with torsades de pointes after therapeut1c administration of terfenadine, a long acting histamine Hl receptor antagonist, together with ketoconazole, an antifungal preparation.
The patient is a 43-year-old female, who experienced palpitation, dizziness and syncopal episoders after coadministration of terfenadine and ketoconazole, for a fungal infection of the skin. The ECG showing typical episodes of torsades de pointes with QT prolongation. Magnesium sulfate was given, torsades de pointes did not recur. The patient was discharged with improved condition.
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| Key words:
Torsades de pointes, Ventricular tachycardia, Terfenadine, Ketoconazole |
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