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Journal of The Korean Society of Emergency Medicine 1995;6(1): 143-153. |
| COMPARATIVE ANALYSIS OF ATROPINE EFFICACIES ON ORGANOPHOSPHOROUS OR CARBAMATE POISONINGS |
| Jae Hwang Park, Jae Kyoo Lee |
| Department of Emergency Medicine, Wonkwang University School of Medicine, Iksan, Korea |
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Published online: June 30, 1995. |
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| ABSTRACT |
Study objective : This study compared analysis of atropine efficacies on organophosphorous or carbamate poisoning after intravenous atropine administration.
Design
Retropsective, blinded, clinical study conducted from January 1990 to December 1993.
Setting
The Wonkwang university hospital emergency department.
Participants : Two hundred forty-three patient who presented with organophosphorous or carbamate intoxication.
Interventions : Eligible subjects received 8.0mg(16ml)/1 hour by syringe pump until full atropinization(eg., full dilatation of pupil, 160 times/min> heart rate, atropine psychosis, decresed secretion or salivation ), and then atropine tapering was done.
Measurements & main results : Forty-eight organophosphorous intoxication patients and twenty-one carbamate intoxication patients completed the study because one hundred seventy-four patients were unknown with the amount of organophosphorous or carbamate ingestion or done
not followed the prescribed atropinization schedule. The followings are the results.
(1) The amounts of organophosphorous or carbamate ingestion were significantly correlated with the total amount of atropine(organophosphorous P : 0.0008, carbamate P : 0.0001), the amount of full atropinization (organophosporous P : 0.0011, carbamate P : 0.0001 ).
(2) The small amount of insecticide ingestion were needed more intravenous atropine administration to carbamate intoxication than organophosphorous intoxication and the large amount of insecticide ingestion were needed more intravenous atropine administration to organophosphorous intoxication than carbamate intoxication.
Conclusion
The organophosphorous or carbamate detoxification were significantly correlated with the total amount of atropine and the amount of full atropinization. The organopho sphorous intoxication is less efficacy and required more atropine administration amount to comparison with carbamate for the detoxification of the large amount.
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| Key words:
Organophosphorous ingestion, Carbamate ingestion, Detoxification, Total amount of atropine, Amount of full atropinization |
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